Preheat the oven to 350°F.
Cook pasta according to the package until al dente
While the pasta is boiling, make the cheese sauce in a medium saucepan.
Melt the butter in the saucepan on medium heat. Once melted, add the flour and dried mustard. Whisk until it is smooth.
Once the butter/flour mixture is smooth, add the milk in slowly, whisking the entire time until smooth.
Add the half and half to the butter/milk mixture and whisk. Bring to a low boil.
Turn off the heat and in the cream cheese. Stir until the cream cheese is melted into the mixture.
Add the shredded cheeses into the sauce mixture one handful at a time. Stir in between each handful of cheese. Add another handful once it is incorporated.
Once the Cheese Sauce is creamy add in the 1/4 teaspoon Liquid Smoke Flavor. Stir well.
Once the pasta is cooked, drain off the liquid and combine the pasta to the sauce. Toss them together until coated.
Add the Macaroni and Cheese to a buttered 2 quart dish.
Combine the Panko breadcrumbs and 1/4 cup melted butter. Mix together.
Sprinkle the breadcrumb mixture on top of the macaroni and cheese.
Bake for 30 minutes or until bubbly.